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Pharmaceutical Compound of Considerable Interest

Tesofensine: The incredible uses and benefits of this peptide

In this article, we will discuss the must-have peptide: Tesofensine

In short, Tesofensine is an incredible peptide that has effective solutions for many healthcare issues, such as:

  1. Weight management solutions
  2. Increasing basal metabolic rate
  3. Lowering levels of risk-associated biomarkers 

And we’ll discuss these in detail throughout this article. 

If you are a beginner to Peptide Therapy then you can view our Peptide Therapy introduction guide and also book a consultation with us to learn more about Peptide Therapy homepage.

In the ongoing pursuit of effective weight management solutions, Tesofensine has emerged as a pharmaceutical compound of considerable interest. This article provides a detailed exploration of Tesofensine, including its chemical composition, mode of action, potential benefits and dosage. 

Early research shows that Tesofensine was originally developed as a treatment for neurodegenerative disorders such as Alzheimers and Parkinsons disease but lacked efficacy. 

A clinical trial highlighting the repurposing of Tesofensine for weight management gained attention in such trials. 

So, let’s get started on our deep-dive into the miraculous ability of Tesofensine Peptide Therapy.

Serotonin-noradrenaline-dopamine reuptake Inhibitor

What is it and how does it work?

Tesofensine is a compound that belongs to a group known as serotonin-noradrenaline-dopamine reuptake inhibitors (SNDRI).
As mentioned above, it was originally developed as a potential treatment for neurodegenerative disorders however, it has gained significant attention for its potential other benefits.
The chemical structure of Tesofensine is characterised by its ability to interact with specific neurotransmitter systems in the brain, which play a pivotal role in regulating appetite, mood and overall energy balance.
The primary neurotransmitters targeted by Tesofensine are serotonin, noradrenaline and dopamine. These chemicals are crucial for various physiological functions and psychological well-being.
Tesofensine exerts its effects by inhibiting the reuptake of these neurotransmitters, preventing their removal from the synaptic cleft (tiny gap between nerve cells). As a result, there is a higher concentration of these neurotransmitters in the synaptic cleft leadinging to several significant physiological and psychological effects:

  • Serotonin: An increase in serotonin levels can contribute to an improved mood and a sense of well-being. This may help individuals using Tesofensine experience enhanced emotional stability and potentially reduce emotional eating 
  • Noradrenaline: Increased noradrenaline levels can stimulate the “fight” or “flight” response in the body, which can lead to increased alertness and energy expenditure. This effect may help boost metabolic rate and calorie burning 
  • Dopamine: Dopamine is a key neurotransmitter involved in the rewards and pleasure pathways of the brain. By increasing dopamine levels, Tesofensine may lead to a reduced sense of craving and reward-driven eating behaviour. 

In summary, Tesofensine’s mechanism of action centres on its ability to modulate these neurotransmitter systems in the brain. By inhibiting the reuptake of serotonin, noradrenaline and dopamine, it can influence mood, appetite regulation and energy balance.
This ultimately results in a feeling of fullness, reduced cravings and enhanced satiety, making it a proposed option for weight management.
In September 2007 “NeuroSearch reported the outcome of a Phase IIb study with Tesofensine for the treatment of obesity. Data from the study in 203 patients showed that 24-weeks’ treatment with tesofensine resulted in a  dose-dependent weight loss of 6.5%-12%. Tesofensine was reported to have a good safety profile and was well tolerated”.
This shows how long Tesofensine has been around and tested.
Isn’t that great?

What are the benefits/ any side effects?

As mentioned by the earlier studies conducted on Tesofensine, it demonstrated a favourable safety record and was well-received by users. 

There are a plethora of studies which highlight the benefits of Tesofensine through multiple clinical studies conducted around the world through various lengths and periods of time. 

Let’s explore the benefits of Tesofensine when it comes to basal metabolic rate, appetite and biomarkers.

Does it increase basal metabolic rate?


Tesofensine is believed to increase the basal metabolic rate (BMR) through its intricate mechanisms of action in the body. The BMR refers to the number of calories that the body burns at rest to maintain essential functions such as respiration, circulation and cellular processes. 

This effect can be particularly valuable in the context of weight management. 

A higher BMR means that the body expends more energy even when at rest, which can have a significant impact on overall energy balance and weight management.

By influencing neurotransmitters in the brain, it can lead to greater energy expenditure, thus helping individuals burn more calories while at rest. 

Tesofensine’s ability to influence BMR can be attributed to its effect on specific neurotransmitters, primarily noradrenaline. When Tesofensine inhibits the reuptake of noradrenaline in the synaptic cleft, it leads to an increased concentration of this neurotransmitter.

As a result, the presence of elevated noradrenaline levels can stimulate various physiological responses that contribute to an enhanced BMR: 

  • Thermogenesis: Noradrenaline can stimulate thermogenesis which is the production of heat by the body. This process involves the activation of brown adipose tissue, commonly referred to as “brown fat”, which is specialised in burning calories to produce heat. An increase in thermogenesis can lead to greater calorie expenditure, even when the body is at rest. 
  • Lipolysis: Tesofensine’s influence on noradrenaline levels can also promote lipolysis, the breakdown of stored fat into free fatty acids. These fatty acids can be used as an energy source, contributing to increased energy expenditure and a reduced fat mass over time.  

The enhancement of basal metabolic rate by Tesofensine has been investigated in a study published by Huynh, Kim, et al. Randomised controlled trial of Tesomet for weight loss in hypothalamic obesity”. The research indicated that Tesofensine increased resting energy expenditure and fat oxidation, contributing to weight loss.

Does it reduce physical hunger and mental cravings?

Ofcourse, yes!

We’ve mentioned how beneficial Tesofensine is when in comes to weight management but its also helps reduce mental cravings. 

As you’ve read above, you know how important Tesofensine is when it comes to serotonin, noradrenaline and dopamine. When it comes to reducing physical hunger, Tesofensine in relation to serotonin and noradrenaline is where you need to look:

Tesofensine’s impact on physical hunger reduction is intricately linked to its modulation of serotonin, a neurotransmitter associated with mood regulation and satiety. By inhibiting the reuptake of seroti=onin, Tesofensine elevates serotonin levels in the synaptic cleft. This elevation contributes to a heightened sense of fullness and satisfaction after meals, ultimately reducing the drive to consume additional calories. Serotonin’s role in the regulation of satiety is well-documented in scientific literature, and Tesofensine’s effect on this neurotransmitter is central to its appetite-suppressing properties.

Let’s move onto Tesofensine and noradrenaline when it comes to physical hunger. 

The stimulation of noradrenaline levels, a key feature of Tesofensine’s mechanism of action, also plays a significant role in reducing physical hunger. Noradrenaline is known to activate the body’s “fight or flight” response, leading to heightened alertness and vigilance. This increased alertness can, in turn, reduce the sensation of hunger by diverting the focus away from food consumption. 

That leaves Tesofensine and mental cravings and with that, you need to look at one pathway: the dopamine and reward pathways. 

Tesofensine’s ability to reduce mental cravings can be attributed to its influence on dopamine, a neurotransmitter critical for the brain’s reward and pleasure pathways. Dopamine plays a pivotal role in the brain’s response to pleasurable experiences, including the consumption of palatable, high calorie foods. By enhancing dopamine activity, Tesofensine reduces the cravings for these rewarding foods. This reduction is scientifically grounded in the notion that elevated dopamine levels can dampen the desire for indulgent food items.

Tesofensine lowers levels of risk associated with biomarkers such as ‘bad’ cholesterol

Tesofensine’s potential to influence risk-associated biomarkers, particularly lipid profiles, is particularly a subject of interest. 

Although Tesofensine is not primarily designed as a lipid-lowering agent, its effects on body weight and metabolism can indirectly impact these important cardiovascular risk factors. 

Tesofensine’s influence on lipid profiles and other risk-associated biomarkers have been researched with the aim to understand how the weight loss achieved with Tesofensine could result in improved cardiovascular health. 

The primary biomarker of interest found amongst many studies was low density lipoprotein cholesterol (LDL-C), often referred to as ‘bad’ cholesterol. Elevated levels of LDL-C are strongly associated with an increased risk of atherosclerosis, heart disease and stroke. The findings of the study suggested that individuals who underwent weight loss with Tesofensine experienced a reduction in LDL-C levels. This reduction is particularly significant because it represents an improvement in a key cardiovascular risk factor. 

Dosage and how to take it

Having delved into the scientific aspects and advantages of Tesofensine, we believe you’ll be enthusiastic to explore this remarkable peptide, especially if you’re new to the realm of peptide therapy and looking for a convenient, non intrusive option.

To begin your Tesofensine journey, all you need to do is arrange a consultation with our Integrative and Functional Medicine practitioner, Jessica. With her extensive experience in the realm of Peptide Therapy, you’ll be in capable hands, ready to tailor your experience to your unique needs.

These consultations are available for international clients, and are not subject to the UK only.

Promising option

Why Nūūtro pioneers Tesofensine Peptide Therapy

When it comes to unlocking the potential of Tesofensine, it’s essential to approach the abundance of information available with a discerning perspective 

The world of peptides are constantly evolving, and Tesofensine represents a promising option.

In contrast to the multitude of sources that might leave you feeling confused or uncertain, here at Nūūtro we distinguish ourselves through unwavering commitment. We are dedicated to offering the highest standards of quality, safety and integrity. 

Within Nūūtro, you can place your trust in the knowledge that our team and products are guided by an unrelenting pursuit of well-being. We understand that your journey towards health is unique, and we’re thrilled to be a part of that transformation. We are here to provide guidance every step of the way. 

Our resolute commitment to your well-being is evident in every aspect of our operations:

  • We only source our peptides from accredited USA-labs that use the purest ingredients.
  • Jessica has personally met the owner and COO of our peptide supplier, we only do business with integrity.
  • Our peptides are rigorously third-party tested.
  • We work with you to discuss other issues such as gut inflammation and hormonal disbalance prior to ensuring the peptides work to their full efficacy.

Begin your transformative journey with Nūūtro, where we are ready to assist you in reaching your wellness goals. 

To learn more about our Peptide Therapy programmes click here.

Enquire Today

To learn more about our Peptide Therapy, please request an appointment at info@nuutro.co.uk