Tesofensine: The incredible uses and benefits of this peptide

Yes! 

Tesofensine is believed to increase the basal metabolic rate (BMR) through its intricate mechanisms of action in the body. The BMR refers to the number of calories that the body burns at rest to maintain essential functions such as respiration, circulation and cellular processes. 

This effect can be particularly valuable in the context of weight management. 

A higher BMR means that the body expends more energy even when at rest, which can have a significant impact on overall energy balance and weight management.

By influencing neurotransmitters in the brain, it can lead to greater energy expenditure, thus helping individuals burn more calories while at rest. 

Tesofensine’s ability to influence BMR can be attributed to its effect on specific neurotransmitters, primarily noradrenaline. When Tesofensine inhibits the reuptake of noradrenaline in the synaptic cleft, it leads to an increased concentration of this neurotransmitter.

As a result, the presence of elevated noradrenaline levels can stimulate various physiological responses that contribute to an enhanced BMR: 

• Thermogenesis: Noradrenaline can stimulate thermogenesis which is the production of heat by the body. This process involves the activation of brown adipose tissue, commonly referred to as “brown fat”, which is specialised in burning calories to produce heat. An increase in thermogenesis can lead to greater calorie expenditure, even when the body is at rest. 
• Lipolysis: Tesofensine’s influence on noradrenaline levels can also promote lipolysis, the breakdown of stored fat into free fatty acids. These fatty acids can be used as an energy source, contributing to increased energy expenditure and a reduced fat mass over time.  

The enhancement of basal metabolic rate by Tesofensine has been investigated in a study published by Huynh, Kim, et al. Randomised controlled trial of Tesomet for weight loss in hypothalamic obesity”. The research indicated that Tesofensine increased resting energy expenditure and fat oxidation, contributing to weight loss.

Of course, yes!

We’ve mentioned how beneficial Tesofensine is when in comes to weight management but its also helps reduce mental cravings. 

As you’ve read above, you know how important Tesofensine is when it comes to serotonin, noradrenaline and dopamine. When it comes to reducing physical hunger, Tesofensine in relation to serotonin and noradrenaline is where you need to look:

Tesofensine’s impact on physical hunger reduction is intricately linked to its modulation of serotonin, a neurotransmitter associated with mood regulation and satiety. By inhibiting the reuptake of serotonin, Tesofensine elevates serotonin levels in the synaptic cleft. This elevation contributes to a heightened sense of fullness and satisfaction after meals, ultimately reducing the drive to consume additional calories. Serotonin’s role in the regulation of satiety is well-documented in scientific literature, and Tesofensine’s effect on this neurotransmitter is central to its appetite-suppressing properties.

Let’s move onto Tesofensine and noradrenaline when it comes to physical hunger. 

The stimulation of noradrenaline levels, a key feature of Tesofensine’s mechanism of action, also plays a significant role in reducing physical hunger. Noradrenaline is known to activate the body’s “fight or flight” response, leading to heightened alertness and vigilance. This increased alertness can, in turn, reduce the sensation of hunger by diverting the focus away from food consumption. 

That leaves Tesofensine and mental cravings and with that, you need to look at one pathway: the dopamine and reward pathways. 

Tesofensine’s ability to reduce mental cravings can be attributed to its influence on dopamine, a neurotransmitter critical for the brain’s reward and pleasure pathways. Dopamine plays a pivotal role in the brain’s response to pleasurable experiences, including the consumption of palatable, high calorie foods. By enhancing dopamine activity, Tesofensine reduces the cravings for these rewarding foods. This reduction is scientifically grounded in the notion that elevated dopamine levels can dampen the desire for indulgent food items.

Tesofensine’s potential to influence risk-associated biomarkers, particularly lipid profiles, is particularly a subject of interest. 

Although Tesofensine is not primarily designed as a lipid-lowering agent, its effects on body weight and metabolism can indirectly impact these important cardiovascular risk factors. 

Tesofensine’s influence on lipid profiles and other risk-associated biomarkers have been researched with the aim to understand how the weight loss achieved with Tesofensine could result in improved cardiovascular health. 

The primary biomarker of interest found amongst many studies was low density lipoprotein cholesterol (LDL-C), often referred to as ‘bad’ cholesterol. Elevated levels of LDL-C are strongly associated with an increased risk of atherosclerosis, heart disease and stroke. The findings of the study suggested that individuals who underwent weight loss with Tesofensine experienced a reduction in LDL-C levels. This reduction is particularly significant because it represents an improvement in a key cardiovascular risk factor. 

Having delved into the scientific aspects and advantages of Tesofensine, we believe you’ll be enthusiastic to explore this remarkable peptide, especially if you’re new to the realm of peptide therapy and looking for a convenient, non intrusive option.

To begin your Tesofensine journey, all you need to do is arrange a consultation with our Integrative and Functional Medicine practitioner, Jessica. With her extensive experience in the realm of Peptide Therapy, you’ll be in capable hands, ready to tailor your experience to your unique needs.

These consultations are available for international clients, and are not subject to the UK only.