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5-Amino-1 MQ: An exploration into its benefits and uses

In this article, we embark on an enlightening discussion on the peptide 5-Amino-1MQ, an intriguing compound that holds the promise of revolutionising various fields. 

If you are new to the realm of cutting-edge peptides and their potential applications, you can explore our Peptide Therapy introduction guide and also book a consultation with us to learn more about Peptide therapy homepage.

So let’s get into the extraordinary capabilities on 5-Amino-1MQ and unlock its potential benefits.

5-Amino-1 MQ

What is it and how does it work?

5-Amino-1MQ is a peptide with its chemical structure consisting of a quinoline ring with a methyl group (CH3) and an amino group (NH2) attached to it.

This compound is interesting because of its ability to interact with biological systems, which make it useful for a variety of purposes.

5-Amino-1MQ is a small molecule that blocks the activity of an enzyme called nicotinamide N-methyltransferase (NNMT).

You may wonder, why is this important?

Well according to this study looking at the Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes:

“NNMT is predominantly expressed in the liver and adipose tissues. NNMT might regulate Sirt1 protein stability. Indeed, NNMT can regulate the ubiquitin-proteasome degradation of Sirt1, thereby stabilising Sirt1 protein”

SIRT1 is known as the “longevity gene” because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease. 

Research conducted on mice treated with 5-amino-1MQ revealed “Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels. Notably, administration of NNMT inhibitors did not impact total food intake nor produce any observable adverse effects. These results support development of small molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target to treat obesity and related metabolic conditions.” This research suggests that the inhibition of NNMT may have the potential to deduce the size of fat cells and diminish fat deposits. 

We’ll delve into this a bit deeper when we look at the benefits of 5-Amino-1MQ!

5-Amino-1MQ is a small molecule that acts as an analogue of naturally occurring methylquinolinium. It possesses the ability to cross cell membranes and has shown potential therapeutic benefits in various areas, particularly related to metabolism, diabetes, weight control and insulin resistance. 

What are the benefits?

5-Amin-1MQ is interesting as a NNMT inhibitor because it is a structural analog of nicotinamide, a substrate of NNMT. 

This means that by competing with nicotinamide, 5-Amino-MQ can inhibit NNMT activity, potentially leading to the benefits mentioned below:

  • Cancer therapy: in some cancers, NNMT is overexpressed, and inhibiting it may help slow down the growth of cancer cells. Inhibition of NNMT can also sensitise cancer cells to certain chemotherapeutic agents, making them more susceptible to treatment. 
  • Metabolic Disorders: NNMT has been linked to metabolic disorders such as obesity, diabetes and fatty liver acids. By inhibiting NNMT, it may help regulate metabolism and reduce the risk of these conditions
  • Anti-Inflammatory Effects: Inhibition of NNMT can have anti-inflammatory effects as it reduces the production of pro-inflammatory molecules. This can prove to be beneficial in various inflammatory conditions
  • Ageing and Longevity: Some research suggests the possibility that NNMT activity increases with age. Inhibiting NNMT will mean that the ageing process could slow down and potentially extend lifespan

5-Amino-1MQ has been studied in various preclinical and some clinical studies as a potential inhibitor for NNMT for cancer therapy, metabolic disorders and other conditions.

Can 5-Amino-1MQ improve neuromuscular function?

The short answer, yes!

The impact of 5-Amino-1 MQ on neuromuscular function is multifaceted. 

The presence of 5-amino-1MQ in muscle promotes the production of the GLUT4 receptor and boosts the inefficiency of metabolism leading to increased energy burn.

Recent research conducted on mice, however, suggests that inhibiting NNMT in any way, including with 5-amino-1MQ, may actually boost muscle repair by stimulating stem cells.

“We recently developed small molecule inhibitors of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed with ageing in skeletal muscles and linked to impairment of the NAD+ salvage pathway, dysregulated sirtuin 1 activity, and increased muSC senescences.

Results revealed that muscle stem cell proliferation and subsequent fusion were elevated in NNMTi-treated mice, supporting nearly 2-fold greater CSA and shifts in fibre size distribution to greater proportions of larger sized myofibers and fewer smaller sized fibres in NNMTi-treated mice compared to controls

Taken together, these results provide the first clear evidence that NNMT inhibitors constitute a viable pharmacological approach to enhance aged muscle regeneration by rescuing muSC function, supporting the development of NNMTi as novel mechanism-of-action therapeutic to improve skeletal muscle regenerative capacity and functional recovery after musculoskeletal injury in older adults”

Does 5-Amino-1MQ reduce muscle soreness?

Muscle soreness typically occurs as a result of inflammation, microtrauma and muscle tissue repair processes following intense physical activity. 

As 5-Amino-1MQ has anti-inflammatory and tissue repair properties, it indirectly contributes to reducing muscle soreness. Here is how it works:

Anti-Inflammatory Effects: 

  • Inflammation is a key component of muscle soreness. As 5-Amino-1MQ has anti-inflammatory properties, it helps to reduce the inflammatory response in muscles after exercise, potentially lessening the soreness associated with it. 

Tissue Repair and Recovery:

  • Muscle soreness often occurs as muscles undergo repair and adaptation to the physical stress placed on them during exercise. Compounds that support tissue repair and recovery such as 5-Amino-1MQ may help reduce the duration and intensity of muscle soreness. 

Neuroprotective Effects:

  • Some reports suggest that 5-Amino-1MQ may have neuroprotective effects. While this is not directly related to muscle soreness, it’s possible that compounds with neuroprotective properties can indirectly improve the perception of soreness and discomfort. 

Does 5-Amino-1MQ lower cellular senescence?

Cellular senescence is a state in which cells lose the ability to divide and function normally, hence its association with ageing and age-related diseases. 

Here are some mechanisms by which 5-Amino-1MQ may lower celli;ar senescence:

Inhibiting NNMT: We know by now that 5-Amino-1MQ is known to inhibit NNMT and this brings huge benefits. High NNMT activity has been associated with increased cellular senescence so by inhibiting NNMT, 5-Amino-1MQ can reduce the production of methylated nicotinamide metabolites that contribute to senescence. 

NAD+ Restoration: Nicotinamide adenine dinucleotide (NAD+) is a coenzyme involved in various cellular processes, including DNA repair and maintenance of cell function. Cellular senescence is associated with NAD+ decline. 5-Amino-1MQ, by regulating nicotinamide metabolism, may help maintain NAD+ levels, potentially slowing down senescence

Anti-inflammatory effects: As mentioned previously, 5-Amino-1MQ has been investigated for its anti-inflammatory properties. Inflammation is a contributor to cellular senescence and because of the properties 5-Amino-1MQ possesses, it can indirectly reduce senescence by mitigating the inflammatory environment in tissues. 

Metabolic Regulation: 5-Amino-1MQ has been studied for its effects on metabolism and metabolic dysregulation actually can promote cellular senescence. By helping to maintain metabolic homeostasis, 5-Amino-1MQ may have a protective effect against senescence. 

Dosage and how to take it

After reading our science backed article on 5-Amino-1MQ, we know you will be wanting to give it a try, especially if you’re just discovering Peptide Therapy. 

The safety profile and potential side effects of any compound can vary depending on factors such as dosage, individual characteristics and interactions with other medications or conditions, 

You can acquire any of our peptides by booking in a consultation with our Integrative and Functional Medicine practitioner, Jessica, who has years of experience working with Peptide Therapy and will be with you on your journey!

These consultations are available for international clients, and are not subject to the UK only.  

Potential Benefits

Why Nūūro is Gold-Standard in Peptide Therapy

When it comes to exploring the potential of 5-Amino-1MQ, it’s important to navigate through a sea of information with a discerning eye. The world of health and wellness is brimming with evolving trends and promising discoveries, and 5-Amino-1MQ is no exception. 

Unlike the multitude of sources that might leave you puzzled or uncertain, our commitment at Nūūtro is unwavering. We stand apart in our dedication to providing you with the highest standards of quality, safety and integrity. 

Here at Nūūtro, you can trust that our team and products are driven by a relentless pursuit of well-being. We understand that your health journey is unique, and we’re excited to be part of that transformation. We’re here to guide you every step of the way. 

Our unwavering commitment to your health is reflected in every facet of what we do:

  • We only source our peptides from accredited USA-labs that use the purest ingredients.
  • Jessica has personally met the owner and COO of our peptide supplier, we only do business with integrity.
  • Our peptides are rigorously third-party tested.
  • We work with you to discuss other issues such as gut inflammation and hormonal disbalance prior to ensuring the peptides work to their full efficacy. 

Embark on a transformative journey with Nūūtro where we can help you achieve your wellness goals. 

To learn more about our Peptide Therapy programmes click here.

Enquire Today

To learn more about our Peptide Therapy, please request an appointment at info@nuutro.co.uk