In the absence of overt disease, chronic fatigue is often overlooked yet it may reflect a disruption in the body’s core energy systems.
While it is commonly attributed to psychological stress, poor sleep, or nutritional imbalance, a growing body of research suggests that mitochondrial dysfunction may be a central contributor to persistent fatigue, especially in individuals whose symptoms remain unresolved through conventional approaches.
Mitochondria are responsible for producing adenosine triphosphate (ATP), the primary energy currency of the body. When mitochondrial function is impaired, whether through oxidative stress, inflammation, toxin accumulation, or nutrient deficiency, cellular energy production declines.
This can result in multisystemic symptoms, particularly fatigue, cognitive dysfunction, exercise intolerance, and immune dysregulation.
Common Signs and Clinical Indicators
Patients experiencing mitochondrial dysfunction often report:
- Persistent fatigue unrelieved by rest
- Brain fog and memory lapses
- Slow post-exertional recovery
- Cold extremities or poor thermoregulation
- Low mood, apathy, or hormonal imbalances
This is not the result of inadequate effort, but a disruption in bioenergetic processes, a form of cellular inefficiency that limits the body’s ability to sustain energy output and recover from physiological stressors.
Contributing Factors to Mitochondrial Dysfunction
The causes of mitochondrial decline are multifactorial and often cumulative:
- Chronic inflammation (e.g. from gut dysbiosis, infection, or stress)
- Environmental toxins, including heavy metals, mycotoxins, and air pollutants
- Oxidative stress and mitochondrial DNA damage
- Nutrient deficiencies such as magnesium, B vitamins, and CoQ10
- Viral load or post-viral syndromes, including long COVID presentations
These factors impair ATP synthesis, increase reactive oxygen species, and compromise the ability of mitochondria to regulate energy output efficiently.
Peptide Therapy in Mitochondrial Support
Peptides are signalling molecules composed of amino acids that influence biological pathways at the cellular level.
Certain peptides have shown promise in modulating mitochondrial performance by improving energy metabolism, reducing oxidative stress, and enhancing tissue repair.
At Nūūtro, peptide protocols are designed based on individual needs and presentations.
Peptides commonly included in mitochondrial-focused protocols include:
- MOTS-c – a mitochondrially derived peptide that supports metabolic flexibility, glucose uptake, and ATP production, especially under stress conditions.
- BPC-157 – a peptide with gut-repair and anti-inflammatory properties, which may support mitochondrial function indirectly by reducing systemic burden and restoring gut barrier integrity.
- Thymosin Beta-4 – involved in tissue repair and immune modulation, which may reduce inflammatory interference in mitochondrial activity.
- GHK-Cu – a copper peptide known to support mitochondrial DNA repair, reduce oxidative stress, and assist in tissue regeneration.
These peptides do not act as stimulants. Instead, they re-engage mitochondrial signalling and repair processes, providing a more sustainable foundation for energy restoration.
Explore our Knowledge Library to learn how different peptides work, and which ones might be right for you.
Adjunctive Therapies: The Role of Ozone
In addition to peptide therapy, ozone (O₃) is utilised at Nūūtro as a clinical intervention to support detoxification, improve oxygen utilisation, and modulate oxidative stress.
When administered in controlled clinical settings, ozone enhances mitochondrial function by improving oxygen metabolism, reducing microbial load, and stimulating antioxidant response elements.
The combination of medical-grade ozone and bioactive peptides provides a dual approach: one focused on clearing metabolic byproducts, the other on rebuilding intracellular energy systems.
Protocol Design at Nūūtro
We design clinical-grade peptide plans based on your biology, your symptoms, and your goals.
Each therapeutic plan begins with a comprehensive 1:1 consultation. We assess your medical history, current symptoms, and optional laboratory markers to inform protocol structure.
Month 1: Onboarding and Delivery
Your peptides are dispensed in pre-prepared vials or pens, no mixing required. They are delivered directly to your door or available for collection from our Mayfair clinic.
Months 2–3: Monitoring and Optimisation
You will receive ongoing clinical support, including regular check-ins, protocol adjustments, and outcome tracking. No two plans are fixed, each is dynamically adjusted based on your response.
All peptides at Nūūtro are sourced from FDA-approved and DEA-compliant laboratories, and undergo rigorous third-party tests to ensure they are free of contaminants, fillers, and heavy metals.
Plans start from £400/month, including a clinical consultation, personalised multi-peptide protocol, and ongoing 1:1 expert support rooted in real clinical insight.
Addressing Energy Loss at Its Source
For individuals experiencing persistent fatigue, the underlying cause is often not psychological or behavioural, but biological.
Mitochondrial dysfunction offers a well-supported explanatory model for chronic fatigue, particularly in individuals with multisystem complaints or poor response to conventional treatments.
At Nūūtro, our approach targets the root cause of cellular energy loss using evidence-informed peptide and ozone therapy, delivered in a structured, clinically monitored format.
To determine whether a peptide protocol targeting mitochondrial function is appropriate for your presentation, we invite you to schedule a free consultation with our clinical team.