Chronic Lyme disease and post-viral syndromes such as Long COVID are increasingly associated with persistent immune dysregulation and low-grade systemic inflammation.
In many cases, standard diagnostics may fail to identify a clear pathology, despite the presence of ongoing symptoms that impair cognitive, physical, and neurological function.
A growing body of research suggests that these conditions are often characterised by elevated inflammatory cytokines, prolonged immune activation, and impaired metabolic clearance.
Individuals frequently report symptoms including fatigue, brain fog, joint pain, autonomic dysregulation, and non-specific neuroinflammatory markers, all of which suggest an underlying inflammatory loop that has failed to resolve.
Understanding Inflammatory Cytokines in Post-Infectious States
Cytokines are signalling proteins that regulate immune responses.
In a normal immune reaction, cytokines such as IL-6, TNF-α, and CRP rise temporarily in response to infection, injury, or cellular stress, before returning to baseline once resolution occurs.
However, in post-infectious syndromes, this regulatory feedback loop can become impaired. Cytokine production continues in the absence of an active infection, leading to chronic, unresolved inflammation.
A 2024 study published in Frontiers in Immunology found that individuals recovering from COVID-19 showed sustained IL-6 elevations up to 12 months post-infection, with levels 60% higher than controls, suggesting persistent immune activation even in mild cases (Lokau et al., 2024).
Introducing EBO₂ Therapy: Extracorporeal Blood Oxygenation and Ozonation
EBO₂ (Extracorporeal Blood Oxygenation and Ozonation) is a medical-grade therapy used to support systemic detoxification and immune modulation. The procedure involves:
- Drawing blood into a closed-loop system
- Introducing medical ozone (O₃) and oxygen to the blood
- Filtering waste metabolites, inflammatory byproducts, and lipid oxidation compounds
- Re-infusing the cleansed and re-oxygenated blood into circulation
EBO₂ is designed to support immune recalibration by altering the internal environment, modulating inflammatory triggers while optimising oxygen delivery and tissue perfusion.
Clinical Origins and Mechanism
EBO₂ is based on the 10-pass (Multipass) ozone protocol developed by Austrian physician Dr. Johann Lahodny.
His research concluded it may be the only therapy, outside of stem cell therapy, capable of directly activating endogenous stem cells, optimizing repair, restoring immune balance, and significantly improving physical resilience.
This therapy has been used in both clinical and adjunctive settings across Europe and is now emerging in functional and integrative medicine practices globally.
We’ve trained under Dr. Lahodny, following his exact protocols at Nūūtro, integrating this therapy as part of a broader, evidence-informed approach to regenerative care.
We also remain in close contact with other global leaders in ozone therapy to ensure what we offer is not just advanced but evolving.
If you’re curious about what EBO₂ supports in real-world settings, visit our Knowledge Library to explore its clinical applications in cardiovascular disease, chronic infections, immune dysregulation, ADHD, autism, and more.
Targeting Immune Dysregulation in Complex Chronic Conditions
For individuals with post-infectious or chronic inflammatory syndromes, EBO₂ may offer support in the following areas:
- Modulation of elevated cytokine activity, including IL-6, TNF-α, and CRP
- Reduction in systemic inflammatory load
- Improved oxygen utilisation and tissue recovery
- Enhanced clearance of metabolic and microbial byproducts
This is particularly relevant in conditions such as:
- Post-viral fatigue syndromes (e.g., Long COVID)
- Persistent inflammatory responses in chronic Lyme disease
- Autoimmune-adjacent conditions with unclear etiology
- Environmental toxicity with overlapping mitochondrial dysfunction
Clinical Application at Nūūtro
Our EBO₂ protocols begin with an in-depth consultation to review medical history, presenting symptoms, and any prior diagnostic data.
You will receive treatment in our Mayfair clinic, under the supervision of our highly trained medical professionals.
Each protocol is tailored to the individual, no two cases are treated identically, as no two biological presentations are the same.
We may also integrate EBO₂ alongside additional regenerative therapies as clinically indicated, including peptide-based protocols targeting mitochondrial, neurological, and immunological repair.
Combined with the right foundations, and guided 1:1 with expert support, EBO₂ becomes part of a strategy that supports deeper recalibration.
If you are navigating a chronic inflammatory condition such as Long COVID or persistent Lyme disease, and traditional interventions have offered limited progress, EBO₂ may be a viable clinical option.
Book your free consultation today to assess your case and determine whether immune modulation through EBO₂ therapy is suitable based on your presentation, goals, and clinical history.